IV ketamine for treatment-resistant depression in Franklin, TN
Depression is not a character flaw. When antidepressant treatment has not helped enough, it can be difficult to consider another option. Treatment-resistant depression generally means insufficient improvement after at least two antidepressant treatments. Your clinician should review whether those treatments were adequate and discuss the options that fit your situation. NIMH: Depression.
IV ketamine may be considered for selected patients after other treatments have not helped enough. VA/DoD guidance suggests ketamine or esketamine as an augmentation option after several adequate medication trials, rather than initial medication treatment. VA/DoD treatment guidance, summarized by Health.mil.
What the evidence can and cannot tell you
Research supports short-term improvement in some people with treatment-resistant depression. Response is not universal, and longer-term benefit is less certain. A study result cannot predict what an individual will experience. Follow-up should reassess symptoms, side effects, and whether continuing treatment makes sense. VA/DoD treatment guidance, summarized by Health.mil.
Medication, psychotherapy, and brain stimulation are other treatment approaches to discuss with your mental health clinician. NIMH: Depression.
CRNA-administered care and anesthesia-level monitoring
Marla Peterson, CRNA, administers IV ketamine with anesthesia-level monitoring in a private treatment room. Vital signs are continuously monitored during the infusion. The CRNA is present during treatment but does not remain in the room continuously.
Tell the clinic about your current treatments and prescribers. Do not change medication without your prescriber’s guidance. Ask about preparation, transportation home, recovery, and follow-up before your appointment.
What to know about IV ketamine
Ketamine is FDA-approved for anesthesia. Its use for depression, PTSD, and anxiety is off-label. Esketamine nasal spray is a different medication with separate FDA-approved uses; those approvals do not apply to IV ketamine.
Potential risks include sedation, dissociation, blood-pressure changes, breathing problems, misuse, and bladder symptoms. Clinical screening and monitoring matter. Discuss your health history, medications, risks, alternatives, and recovery instructions with your care team. FDA: ketamine safety alert (archived copy linked by FDA).
Pricing, without the guesswork
Mental wellness infusions are $475 each; six infusions total $2,850. The initial phone consultation is free. The number and timing of treatments depend on clinical assessment and response. A six-infusion total is a cost reference, not a promise of results or a requirement for every patient.
Pain infusions have separate duration-based pricing, from $475 to $1,425. MCK: infusion pricing and pain tiers. Ask about your treatment plan and total cost before starting.
Visit Music City Ketamine in Franklin
480 Duke Dr., Suite #100, Franklin, TN 37067. (615) 988-4600. Serving Franklin and the Nashville area from Cool Springs.
Monday–Friday, 9 AM–5 PM. Weekends and evenings by appointment.
Please confirm appointment availability with the clinic.
Questions before you decide
What is treatment-resistant depression?
The term generally describes depression that has not improved sufficiently after at least two antidepressant treatments. A clinician reviews the diagnosis, dose, duration, and response before discussing next steps.
Does IV ketamine work for everyone?
No. Some people improve in the short term; others do not. The size and duration of benefit vary, and longer-term treatment decisions need reassessment.
Is IV ketamine FDA-approved for depression?
No. IV ketamine for depression is off-label. FDA approval of esketamine nasal spray does not extend to IV ketamine.
Can I stop my antidepressant?
Do not start, stop, or change medication without your prescriber. Discuss ketamine as part of your existing care plan.
How to choose a Nashville-area ketamine clinic
Ask who evaluates you and administers treatment, what monitoring and emergency procedures are in place, how recovery and follow-up work, and how the clinic coordinates with your existing providers. Compare total costs, appointment availability, and the evidence for your condition. Look for clear discussion of risks, alternatives, and the possibility of no benefit.
What does treatment cost?
Mental wellness infusions are $475 each; six infusions total $2,850. The initial phone consultation is free. The number and timing of treatments depend on clinical assessment and response. A six-infusion total is a cost reference, not a promise of results or a requirement for every patient.
If you need immediate help
If you are struggling or having thoughts of suicide, call or text 988 or visit 988lifeline.org. In a life-threatening emergency, call 911. A consultation request is not an emergency service.
You don’t have to decide today.
Start with a free phone consultation to talk through your questions. If ketamine is not appropriate, your care team can help you consider other options.